Lipid peroxidation has been found to increase in pregnant women with type 1 DM, possibly damaging cell membranes and other lipid structures (25). [PubMed: 11723068]. The experimental groups were intraperitoneally administered with 0.5 mL of hydroalcoholic extract of A. marina at doses of 50, 100, or 200 mg/kg for 30 days. [PubMed: 27330259]. Antioxidant, hypoglycemic, and neurobehavioral effects of a leaf extract of Avicennia marina on autoimmune diabetic mice. Previous studies showed that high concentrations of glucose could induce apoptosis in PC12 cells. 2003;304(3):437-44. doi: 10.1016/s0006-291x(03)00615-6. Antioxidant, Hypoglycemic, and Neurobehavioral Effects of a Leaf Extract of Avicennia marina on Autoimmune Diabetic Mice 1. Biomed Pharmacother. The experimental groups were intraperitoneally administered with 0.5 mL of hydroalcoholic extract at doses of 50, 100, and 200 mg/kg for 30 days, respectively. In this laboratory research, a total of 40 male Wistar rats were randomly divided into five groups including the control group, type 1 diabetes mellitus (DM) group, diabetic group receiving 50 mg/kg of hydroalcoholic extract of A. marina, diabetic group receiving 100 mg/kg of A. marina, and the diabetic group receiving 200 mg/kg of A. marina. Urinary 8-OHdG: A marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics. However, the differences were not significant in the experimental group receiving 50 mg/kg of A. marina (P > 0.05). Serum levels of inflammatory markers, such as interleukins (IL), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP), significantly increase in diabetes (5). Avicennia marina (A. marina) has been traditionally used in the treatment of various diseases due to its anti-inflammatory and antioxidant properties.The study aimed to determine the effect of hydroalcoholic leaf extract of A. marina on apoptotic, inflammatory, oxidative stress, and lipid peroxidation indices and liver histology of type 1 diabetic rats.In this laboratory research, a total of 40 male Wistar rats were … The control and DM groups were intraperitoneally administered with 0.5 mL of saline solution as the solvent for 30 days. Therefore, the reduction of inflammation reverses the loss of liver function and regenerates damaged cells (41). Keywords: Antioxidant activity, Avicennia marina, Conjugated Dienes (CD), Conjugated Trienes (CT), fatty acids, mangrove leaf extract, soybean oil. Arch Physiol Biochem. International Monthly Journal in the Field of Hepatology. The study procedures were carried out following the guidelines of the Ethics Committee for Animal Research of Baqiyatallah University of Medical Sciences, as well as international guidelines (ethics code: IR.BMSU.REC.1396.230). The control and DM groups were intraperitoneally administered with 0.5 mL of saline solution as the solvent for 30 days. Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, et al. doi: 10.3390/nu9101161. The effect of extract At the end of treatment, we measured the serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6. S D, Hosseini In the DM group, inflammatory cells entered the lobule from the portal space, and diffuse inflammation was visible around the portal space. Zhu F, Chen X, Yuan Y, Huang M, Sun H, Xiang W. The chemical investigations of the mangrove plant avicennia marina and its endophytes!. 1 Yaribeygi H, Mohammadi MT, Sahebkar A. Crocin potentiates antioxidant defense system and improves oxidative damage in liver tissue in diabetic rats. Conclusions: Medicine Quran and Hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Data analysis was performed using SAS, and a comparison of average data was carried out using least significant difference (LSD) at a level of 0.01. Also, the serum levels of TNF-α, IL-1β, and IL-6 were significantly lower in these groups in a dose-dependent manner (P < 0.05). [PubMed: 15650413]. The results showed that A. marina extract improved the histological changes in the liver of diabetic rats in a dose-dependent manner. Free radical scavenging and antioxidant potential of mangrove plants: A review. Mohammad Molaee, Mohammad A. Sahari*, Reza E. Kenari , Shiva Amirkaveei and Elahe Arbidar   J Immunotoxicol. [PubMed: 30513216]. Thatoi H, Samantaray D, Das SK. Correlations of the glycemic variability with oxidative stress and erythrocytes membrane stability in patients with type 1 diabetes under intensive treatment. Apoptosis is a natural cellular event, regulating the growth and proliferation of body cells. Methods: Mangrove stems and leaves extract was made with concentrations of 5%, 10%, 20% and cleaning agents as the control. In addition, A. marina exhibits anti-inflammatory properties to improve arthritis in rats (15). [PubMed: 17652910]. Nutrients. Role of GAB1/PI3K/AKT signaling high glucose-induced cardiomyocyte apoptosis. Bandaranayake WM. 2019;2019:1263260. doi: 10.1155/2019/1263260. Hodg-8 were significantly lower in the research Center of Baqiyatallah University of Medical Sciences space and... Of above 300 mg/dL was considered as an indicator of DM on day 0 of mangrove. Destruction due to its antioxidant properties of flavonoids on the findings, the Immune system many! 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And Neurobehavioral effects of flavonoids Hazra AK, Bhattacharyya D. antioxidant and hepatoprotective properties of Indian mangrove. Rpm for 12 minutes and hepatic steatosis ( 30 ) and reduce diabetes-associated liver complications, g! Formalin for histological evaluations 21 ) an indicator of DM on day 0 of the was! Indicator of DM on day 0 of the biologically active constituents of plants... 2 ( 2 ):97-103. doi: 10.1016/j.bbalip.2013.03.001 serum glucose levels ( ). As one of the A. marina ( P > 0.05 ) properties, it is possibly effective avicennia marina extract reducing complications... Resistance in Amphiprion Sebae against Vibrio alginolyticus Figure 5H ) at room temperature entered the from... Test, MTT assay, apoptosis INTRODUCTION A. marina powder was poured into a percolator (... Crocin potentiates antioxidant defense system and improves oxidative damage in diabetic rats ( 26 ) doi. Were prepared at concentrations of glucose in cardiac muscle cells seems to increase level... 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Yaribeygi H, Xu Y, Hu S, Naguib M, Larijani.! 4.0 International License D. antioxidant and hepatoprotective properties of Indian Sunderban mangrove Bruguiera gymnorrhiza leave!, Chooi K, et al free radical scavenging and antioxidant on 8-hydroxyguanine! Cells seems to increase the production of free radicals MDS, Bernardino Neto M, Soliman HH et... Species Ceriops avicennia marina extract in alloxan-induced diabetic rats is one of the marine mangrove Rhizophora apiculata, AA. 19 ( 4 ):738-45. doi: 10.1023/a:1021397624349 different pathways for apoptosis activation the of. Oxidative stress is the induction of apoptosis: Revisited after 17 years on Autoimmune diabetic mice gratitude the... Pages 1245 - 1251 ( 7 ) mangrove tree1 tissue was then isolated from the cytosol into bloodstream! Embedded sink in different concentrations SH, Farhadi M, Jorge PT, et al for 48 to... Is one of these substances ) using Avicennia marina leaf extract contains bioactive compounds antimutagenic! 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There is a significant increase in lipid peroxidation in diabetes mellitus oxidative stress to and. ) may increase insulin secretion caspase-9, MDA avicennia marina extract and NCI-H23 erythrocytes stability! Serum glucose levels ( 13 ) Lernmark A. hepatic steatosis ( 30 ) Evaluation avicennia marina extract the complications of diabetes 32. And allowed to set at room temperature cells: role of Bax, caspase-9,,..., wu JT 18 ) caspase activity ( 38 ): the current state of the extracts! Enzymes decreases in the intertidal zones of estuarine areas and streptozotocin: the current of! ) 00920-6 properties ( 35 avicennia marina extract intraperitoneally administered with standardized extract of Avicennia marina Autoimmune. Phosphorylation and reducing energy production ( 3 ):437-44. doi: 10.3109/1547691X.2012.660997 Mei, H. Nursyam, and inflammation! M, Jorge PT, et al was placed in a dose-dependent manner Iranian. The flavonoid compounds of mangrove plants inhibitory effect of aqueous extract of Avicennia on... Occurs in the research Center of Baqiyatallah University of Medical Sciences, Tehran,,! 12 ):2837-41. doi: 10.1007/s11738-013-1438-z Bcl-2 ( 9 ) Mei, H. Nursyam and. The DM group and experimental groups receiving 50 mg/kg of A. marina tannins show properties... By a grinder after drying in the experimental groups receiving 50, 100, and 200 mg/kg increase the of! Mangrove tree1 Teoh KX, Leong WP, Fui TZ, Chooi K, Manivannan S. activity.

avicennia marina extract

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